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We exemplify its applicability by imaging hypohalous stress in bacteria phagocytosed by primary neutrophils. Solving the Hypocrates X-ray structure provided insights into its sensing mechanism, allowing determination of the spatial organization in this circularly permuted fluorescent protein-based redox probe. We show that Hypocrates is ratiometric, reversible, and responds to its analytes in the 10 6вЂ‰M в€’1s в€’1 range. Hypocrates consists of a circularly permuted yellow fluorescent protein integrated into the structure of the transcription repressor NemR from Escherichia coli. Here we present a fluorescent genetically encoded biosensor, Hypocrates, for the visualization of (pseudo)hypohalous acids and their derivatives. The lack of tools to monitor the dynamics of (pseudo)hypohalous acids in live cells and tissues hinders a better understanding of inflammatory processes. Nature Communications volumeВ 13, ArticleВ number: 171 ( 2022) Hypocrates is a genetically encoded fluorescent biosensor for (pseudo)hypohalous acids and their derivatives

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